Search results for "interaction [dark matter]"
showing 10 items of 363 documents
Performance of the cost-effective Planacon ® MCP-PMTs in strong magnetic fields
2020
We present the behavior of the cost-effective Planacon MCP-PMTs with pore diameter in the presence of axial magnetic fields up to 0.5 T. Having a batch of 62 devices of the same type, two MCP-PMTs were selected and their gain variation measured in different magnetic fields. These two otherwise identical devices satisfied the selection criteria by requiring the lowest (1.15 kV) and one of the highest (1.4 kV) bias voltage values to achieve a given gain. Both MCP-PMTs have a nearly identical tolerance of the strong magnetic field despite the significant difference in the bias voltage. This clarifies the mechanism of the B-field influence on the MCP-PMT gain, emphasizing the importance of the …
Molecular mechanics models for the image charge, a comment on “including image charge effects in the molecular dynamics simulations of molecules on m…
2017
We re-investigate the image charge model of Iori and Corni (Iori and Corni, J. Comput. Chem. 2008, 29, 1656). We find that a simple symmetrization of their model allows to obtain quantitatively correct results for the electrostatic interaction of a water molecule with a metallic surface. This symmetrization reduces the magnitude of the electrostatic interaction to less than 10% of the total interaction energy. © 2017 Wiley Periodicals, Inc.
Stromal Interaction Molecule 1 (STIM1) Is Involved in the Regulation of Mitochondrial Shape and Bioenergetics and Plays a Role in Oxidative Stress
2012
Calcium ions are involved in a plethora of cellular functions including cell death and mitochondrial energy metabolism. Store-operated Ca(2+) entry over the plasma membrane is activated by depletion of intracellular Ca(2+) stores and is mediated by the sensor STIM1 and the channel ORAI1. We compared cell death susceptibility to oxidative stress in STIM1 knock-out and ORAI1 knockdown mouse embryonic fibroblasts and in knock-out cells with reconstituted wild type and dominant active STIM1. We show that STIM1 and ORAI1 deficiency renders cells more susceptible to oxidative stress, which can be rescued by STIM1 and ORAI1 overexpression. STIM1 knock-out mitochondria are tubular, have a higher Ca…
Hume’s Guillotine in Designing Ethically Intelligent Technologies
2020
Intelligent machines can follow ethical rules in their behaviour. However, it is less clear whether intelligent systems can also create new ethical principles. The former position can be called weak ethical AI and the latter strong ethical AI. Hume’s guillotine which claims that one cannot derive values from facts appears to be a fundamental obstacle to strong ethical AI. The analysis of human ethical information processes provides clarity to the possibility of strong ethical AI. Human ethical information processing begins with positive of negative emotions associated to situations. Situations can be seen as consequences of actions and for this reason people can define rules about acceptabi…
Make It Intuitive: An Evaluation Practice Emergent from the Plans and Scripted Behavior of the Computer-Community of Practice
2012
The catch phrase today for system designers is to “make it intuitive,” which begs the question, what is intuitive? The action research discussed in this article was the final stage of the application of grounded theory to user data that provided survey categories (criteria) for system acceptance. A theoretical rationale from the discipline of human–computer interaction was proposed to provide a consistent and repeatable interpretation of the users’ responses to the survey and directly align the responses to software design considerations. To put this work into context, I discuss in this article a case study on the use of the survey to monitor the user experience during the upgrade of an ent…
Kilencévesek a lakatlan szigeten : az érvelés szituációs beágyazottságának jelei. Esettanulmány
2015
This case study is a qualitative analysis of a video-recorded reasoning situation in which a pair of nine year old children argues for tools that should be taken to a deserted island. The students’ answers to a sociometric questionnaire are taken into account to establish background data on the children’s social positions in their clas and into their relationship. This information was used to interpret the multimodal data. A creative problemsolving task was the context of the reasoning situation, where the children were asked to choose 7 objects from 17 to be taken to a deserted island. Although there are many studies on children’s reasoning, it’s bodily and socially distributed nature has …
Technology in culture : a theoretical discourse on convergence in human-technology interaction
2014
Technology touches so many facets of contemporary life that one is not necessarily conscious any more of how and why it affects daily experience. Awareness of technology’s role often surfaces only when something goes wrong with a product. At that moment, people become aware of a misalignment between their ways of thinking, feeling and behaving, and the form/function of a product, presumably designed to make life easier. Equally ubiquitous and beyond daily awareness are cognitive, affective, and behavioural processes patterned by culture. It has been noted that cultural factors influence the perception and usage of technology. Understanding these processes is important to researchers, design…
Is There Any Hope for Developing Automated Translation Technology for Sign Languages?
2021
This article discusses the prerequisites for the machine translation of sign languages. The topic is complex, including questions relating to technology, interaction design, linguistics and culture. At the moment, despite the affordances provided by the technology, automated translation between signed and spoken languages – or between sign languages – is not possible. The very need of such translation and its associated technology can also be questioned. Yet, we believe that contributing to the improvement of sign language detection, processing and even sign language translation to spoken languages in the future is a matter that should not be abandoned. However, we argue that this work shou…
Prediction of Specific TCR-Peptide Binding From Large Dictionaries of TCR-Peptide Pairs
2019
Abstract The T cell repertoire is composed of T cell receptors (TCR) selected by their cognate MHC-peptides and naive TCR that do not bind known peptides. While the task of distinguishing a peptide-binding TCR from a naive TCR unlikely to bind any peptide can be performed using sequence motifs, distinguishing between TCRs binding different peptides requires more advanced methods. Such a prediction is the key for using TCR repertoires as disease-specific biomarkers. We here used large scale TCR-peptide dictionaries with state-of-the-art natural language processing (NLP) methods to produce ERGO (pEptide tcR matchinG predictiOn), a highly specific classifier to predict which TCR binds to which…
Smart objects: come il digitale organizza la nostra vita
2014
Computer, tablet, smartphone are the most important everyday objects in our life because we made experiences by them; they run due to their software: so it is necessary to understand it, his form, his design and his tradeoffs to understand the role of these objects and the possibilities of a conscious use of them.